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The symmetry of the funnel plot was further evaluated by Egger's linear regression test [6]

These findings suggest that dysbiosis of the gut microbiota plays a pivotal role in HN pathogenesis

Moreover, in a post hoc analysis of the SURPASS-4 randomized clinical trial, tirzepatide decreased albuminuria and total estimated glomerular filtration rate (eGFR) slopes and nearly halved the risk of a pre-specified composite kidney endpoint (eGFR decline 40%, renal death, kidney failure or new-onset macroalbuminuria) in participants with T2DM and high cardiovascular risk when compared with insulin glargine

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Epithalon has been extensively evaluated in aging-prone and cancer-prone rodent models, where it has been shown to reduce spontaneous tumor formation, suppress oncogene expression (notably HER-2/neu), and increase median and maximal lifespan 1,2